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目的:探讨受体酪氨酸激酶Eph B1及其配体Ephrin B1在宫颈鳞癌中的表达水平及其与临床病理特征的关系。方法:采用免疫组化染色法检测Eph B1和Ephrin B1在82例宫颈鳞癌组织中的表达情况,分析其表达与临床病理特征的关系。结果:82例宫颈鳞癌组织中Eph B1和Ephrin B1高表达分别为44例(53.7%)和49例(59.8%),低表达分别为38例(46.3%)和33例(40.2%)。在不同分化程度的宫颈鳞癌组织中Eph B1及Ephrin B1的表达差异有统计学意义(P<0.05),淋巴结转移组中Eph B1及Ephrin B1的表达高于淋巴结未转移组(P<0.05)。Eph B1及Ephrin B1的表达差异与宫颈鳞癌的FIGO分期无关(P>0.05),Eph B1与Ephrin B1表达呈高度正相关(r=0.684,P<0.01)。结论:Eph B1及Ephrin B1的高表达可能与宫颈鳞癌的发生、发展有关,并对判断宫颈鳞癌的生物学行为有一定意义。
Objective: To investigate the expression of Eph B1, a receptor tyrosine kinase, and its ligand Ephrin B1 in cervical squamous cell carcinoma and its relationship with clinicopathological features. Methods: The expressions of Eph B1 and Ephrin B1 in 82 cases of cervical squamous cell carcinoma were detected by immunohistochemistry. The relationship between the expression of Eph B1 and Ephrin B1 and clinicopathological features was analyzed. Results: The high expressions of Eph B1 and Ephrin B1 in 82 cases of cervical squamous cell carcinoma were 44 cases (53.7%) and 49 cases (59.8%), respectively. The low expressions were 38 cases (46.3%) and 33 cases (40.2%). The expressions of Eph B1 and Ephrin B1 were significantly different in cervical squamous cell carcinoma tissues with different differentiation (P <0.05). The expression of Eph B1 and Ephrin B1 in lymph node metastasis group was higher than that in lymph node metastasis group (P <0.05) . The difference of Eph B1 and Ephrin B1 expression was not related to the FIGO staging of cervical squamous cell carcinoma (P> 0.05). The expression of Eph B1 and Ephrin B1 was highly correlated (r = 0.684, P <0.01). Conclusion: The high expressions of Eph B1 and Ephrin B1 may be related to the occurrence and development of cervical squamous cell carcinoma, and have certain significance in judging the biological behavior of cervical squamous cell carcinoma.