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目的观察组合型人工肾(即血液透析联合血液灌流)治疗尿毒症脑病的临床效果。方法 48例尿毒症脑病患者分成组合型人工肾治疗及单纯血液透析治疗两组,分别观测两组治疗前后血尿毒氮(BUN)、血肌酐(Scr)的变化及临床症状的缓解情况。结果两组治疗前后尿素氮、肌酐显著降低(P<0.01);两组治疗后的尿素氮、肌酐无显著性差异(P>0.05),组合型人工肾治疗尿毒症脑病效果明显,有效率100%,P<0.01具有非常显著意义:单纯透析组治疗效果差,有效率41%。结论组合人工肾是治疗尿毒症脑病的必要的有效方法。
Objective To observe the clinical effect of combined artificial kidney (hemodialysis combined with hemoperfusion) on uremic encephalopathy. Methods 48 patients with uremic encephalopathy were divided into combined artificial kidney treatment and hemodialysis treatment. The changes of blood urea nitrogen (BUN), serum creatinine (Scr) and clinical symptoms before and after treatment were observed in two groups. Results The levels of urea nitrogen and creatinine in the two groups were significantly decreased before and after treatment (P <0.01). There was no significant difference between the two groups in the treatment of urea nitrogen and creatinine (P> 0.05). The combination artificial kidney treatment of uremic encephalopathy was effective with 100 %, P <0.01 has a very significant meaning: simple dialysis group treatment effect is poor, the effective rate of 41%. Conclusion Combined artificial kidney is an effective and necessary method to treat uremic encephalopathy.