论文部分内容阅读
目的比较VX2肝癌模型肿瘤不同病变区域的表观扩散系数(ADC)值,进一步探讨MR扩散加权成像(MR-DWI)在肝癌诊断中的价值。材料与方法在CT引导下,对30只新西兰实验兔采用经皮瘤组织块注射法进行种植,制作VX2肝癌模型。分别在种植后第4天、1、2、3周进行MRT1WI、T2WI和DWI扫描。观察不同时间肿瘤中心区、边缘区ADC值差别和变化规律。结果30只实验动物,肿瘤种植成功25只。种植后第4天各种检查方法即可显示肿瘤灶,中心区和边缘区ADC值差异无统计学意义。第1、2周中心区和和边缘区ADC值差异有统计学意义。第3周中心区和边缘区ADC值差异无统计学意义。中心区ADC值在2周前小于周边区,而在第3周高于周边区。结论MR-DWI速度快、简单易行,ADC值的应用将会提高对肝脏疾病的诊断水平。
Objective To compare the apparent diffusion coefficient (ADC) of different lesions in VX2 hepatocellular carcinoma model and to further investigate the value of MR diffusion weighted imaging (MR-DWI) in the diagnosis of liver cancer. MATERIALS AND METHODS Thirty New Zealand rabbits were implanted with percutaneous neoplasm injections under the guidance of CT, and VX2 liver cancer model was made. MRT1WI, T2WI and DWI scans were performed on day 4, 1, 2 and 3 weeks after planting respectively. The difference and change rule of ADC value between tumor center and marginal zone at different time were observed. Results 30 experimental animals, tumor implantation success 25. There were no significant differences in ADC value between the 4th day after planting and the various examination methods. There was a significant difference in ADC value between the first and second weeks in the central area and the marginal area. There was no significant difference in ADC value between the central area and the marginal zone in the third week. The ADC values in the central area were smaller than those in the peripheral area two weeks ago and higher than those in the peripheral area in the third week. Conclusion MR-DWI is fast and easy to perform. The application of ADC value will improve the diagnosis of liver diseases.