髓外浆细胞瘤(extramedullary plasmacytoma,EMP)是一种少见的浆细胞肿瘤,仅占全身浆细胞瘤的1%～2%,可发生于任何髓外组织或器官,约80%患者发生于上呼吸道,常见于鼻腔鼻窦、鼻咽部、口腔[1]。文献报道的EMP多以单发为主,多发、巨大的髓外浆细胞瘤较罕见,现将我院收治的1例多发、巨大的髓外浆细胞瘤报告如下。1临床资料患者男性,42岁,因声音嘶哑1个月、气急10d,于2008年2月11日入住我院耳鼻咽喉科。患者1个月前无明显诱因出现声音嘶哑,无咽痛、气急、咳嗽咳痰、咯血,无吞咽困 Extramedullary plasmacytoma (EMP) is a rare plasma cell tumor that accounts for only 1% to 2% of whole-body plasmacytomas and can occur in any extramedullary tissue or organ, with about 80% of patients developing Respiratory tract, common in nasal sinus, nasopharynx, oral [1]. EMP reported in the literature mostly single hair, multiple, huge extramedullary plasmacytoma is rare, now admitted to our hospital in 1 case of multiple, huge extramedullary plasmacytoma reported as follows. 1 clinical data Male patient, 42 years old, hoarseness for 1 month, shortness of breath 10d, February 11, 2008 admitted to our hospital ENT. Patient 1 month ago no obvious incentive to appear hoarseness, no sore throat, shortness of breath, cough and sputum, hemoptysis, no dysphagia