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目的评价卡维地洛对冠心病心绞痛型患者心率变异性(HRV)的影响。方法冠心病心绞痛型患者120例随机分为卡维地洛组(62例)和对照组(58例),用药前后2周分别记录24h动态心电图,评价患者心率变异性指标的变化。结果两组治疗后心率变异性各参数较治疗前均显著改善(P<0.01),治疗后卡维地洛组较对照组改善更为显著(P<0.01)。结论卡维地洛可以显著提高冠心病心绞痛型患者的心率变异性。
Objective To evaluate the effect of carvedilol on heart rate variability (HRV) in patients with coronary heart disease and angina pectoris. Methods One hundred and twenty patients with angina pectoris were randomly divided into carvedilol group (n = 62) and control group (n = 58). 24h ambulatory electrocardiogram was recorded before and after 2 weeks of treatment to evaluate the changes of heart rate variability. Results After treatment, the parameters of heart rate variability were significantly improved in both groups (P <0.01). After treatment, the carvedilol group improved more significantly than the control group (P <0.01). Conclusion Carvedilol can significantly improve heart rate variability in patients with coronary heart disease.