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熊脱氧胆酸(Ursodeoxycholic Acid,UDCA)作为应用几十年的护肝药物,一直被作为其他护肝药物筛选的阳性对照药。但近年来,随着科学技术的不断进步,人们对肝损伤机制及UDCA保护作用有了更深一步的认识。本文对UDCA在药物性肝损伤(Drug-induced liver injury,DILI)、胆总管结扎(bile duct ligated,BDL)性肝损伤模型的应用情况进行简要概述,以期为UDCA在相关肝胆疾病的应用研究提供参考。
Ursodeoxycholic Acid (UDCA) has been used as a positive control drug for screening other hepatoprotective drugs as a hepatoprotective drug for several decades. However, in recent years, with the continuous improvement of science and technology, people have a deeper understanding of the mechanism of liver injury and the protective effect of UDCA. This review summarizes the application of UDCA in drug-induced liver injury (DILI) and bile duct ligated (BDL) hepatic injury models in order to provide an overview of the application of UDCA in hepatobiliary diseases reference.