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成人胰腺外分泌功能不全和脂痢的关系已作广泛研究。正常人胰腺外分泌功能储备很大。脂酶活性测定不能反映脂肪吸收不良的程度。体外实验中,共脂酶(colipase)能防止胆汁酸微胶粒对脂酶的完全抑制。在胰腺功能低下者,脂肪分解可能由共脂酶控制;作者观察到脂痢患者共脂酶分泌相对较低。本文目的在于1,评价继发于胰腺囊性纤维化、Shwachman综合征和原因不明胰腺发育不全的胰腺功能不全患者中脂酶与共脂酶分泌的范围;2.确定体内胰脂酶与共脂酶在脂肪吸收中的相对地位。作者对24例脂痢儿童(粪脂排泄量超过进食脂肪70%,包括3例Shwachman综合征,1例病因不明的胰腺发育不全,20例胰腺囊性纤维化)和54例脂肪
The relationship between adult pancreatic exocrine insufficiency and fatty diarrhea has been extensively studied. Normal pancreatic exocrine function reserves. Determination of lipase activity does not reflect the degree of fat malabsorption. In vitro experiments, colipase prevents bile acid micelles complete inhibition of lipase. Lipid breakdown may be controlled by the co-lipase in patients with impaired pancreatic function; the authors observed a relatively lower share of total lipase secretion in patients with dysentery. The purpose of this paper is to evaluate the extent of lipase and co-lipase secretion in patients with pancreatic insufficiency secondary to pancreatic cystic fibrosis, Shwachman’s syndrome and unexplained pancreatic hypoplasia; 2. To determine the extent of pancreatic lipase and co- The relative position of fat absorption. The authors evaluated 24 children with lipid-diarrhea (faecal fat excretion exceeding 70% of fat intake, including 3 Shwachman syndrome, 1 case of pancreatic hypoplasia of unknown etiology, and 20 cases of pancreatic cystic fibrosis) and 54 cases of fat