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目的研究肺结核病灶组织γ-干扰素(IFN-γ)表达及其临床意义。方法选取56例肺结核病变组织作为研究组,选取30例正常肺组织作为对照组,采用SP免疫组织化学法对两组肺组织中的IFN-γ表达情况进行分析。结果 IFN-γ主要以胞浆形式表达,对照组IFN-γ阳性表达PU值明显低于研究组,差异具有统计学意义(P<0.05);研究组痰菌阴性和阳性、初治和复治、不同病变面积以及非空洞和空洞之间IFN-γ表达进行比较,差异均无统计学意义(P>0.05)。结论区别正常肺组织与肺结核病变组织的主要特征可能是IFN-γ高表达,其参与结核病的发生发展,可作为辅助诊断结核病的标志物在临床中推广使用。
Objective To study the expression of interferon-γ (IFN-γ) in pulmonary tuberculosis tissues and its clinical significance. Methods Fifty-six patients with pulmonary tuberculosis were selected as the study group and 30 normal lung tissues were selected as the control group. The expression of IFN-γ in lung tissue of the two groups was analyzed by SP immunohistochemistry. Results IFN-γ was mainly expressed in cytoplasm. The PU value of IFN-γ in control group was significantly lower than that in study group (P <0.05). The sputum negative and positive in study group, , The area of different lesions and the expression of IFN-γ between non-vacuoles and cavities were not significantly different (P> 0.05). Conclusions The main feature distinguishing between normal lung tissue and tuberculosis tissue may be the high expression of IFN-γ, which is involved in the occurrence and development of tuberculosis. It may be used as a marker to help diagnose tuberculosis in clinic.