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作者首次研究头颈部鳞癌患者的局部淋巴结的细胞免疫机制,检测颈淋巴结细胞体外调节外周血单核细胞对T细胞有丝分裂原的反应活性,业与临床分期以及淋巴结结构作比较,发现淋巴结细胞有丝分裂原反应的增强与原发肿瘤的体积较大(P<0.05)和分化较差(P<0.02)显著有关。用于本研究的是8例上呼吸道和消化道的Ⅲ、Ⅳ期癌肿,均经外科手术切除,仅1例术前进行过4500rad放射治疗,局部淋巴结细胞调节
The authors first studied the cellular immunity mechanism of regional lymph nodes in patients with head and neck squamous cell carcinoma and examined the in vitro regulation of cervical lymph node cells’ response to peripheral blood mononuclear cells in response to mitogen in T cells. In comparison with clinical stage and lymph node structure, lymph node cells were found. The enhancement of the mitogen response was significantly related to the larger (P<0.05) and poorly differentiated (P<0.02) primary tumors. Eight cases of stage III and IV cancers of the upper respiratory tract and digestive tract were used for this study. All patients underwent surgical resection. Only 1 patient received 4500 rad preoperative radiation therapy and local lymph node cell regulation.