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目的:探讨茵栀黄汤对新生儿黄疸血清总胆汁酸浓度变化影响效果。方法:选取我院儿科收治的新生儿黄疸患儿60例,随机分为两组,其中对照组30例,予常规西医对症治疗,抗感染、纠正酸碱、离子平衡,补液、吸氧等,并给予苯巴比妥5 mg/(kg·d),尼可刹米0.25 g,日1次口服。1周为1疗程,治疗2个疗程。实验组30例,在对照组常规对症治疗基础上,予茵栀黄汤(茵陈10 g,栀子5 g,茯苓10 g,黄芪10 g,大黄5 g,车前草5 g,黄柏5 g,甘草10 g),日1剂水煎早晚分服,1周为1个疗程,治疗2个疗程。治疗结束后,对比各组患儿黄疸及大便状态改变情况、肝功及血清总胆汁酸、胆红素水平改变情况。结果:1试验后各组黄疸及大便性质均在短时间改善,实验组黄疸消退、便质、便次、便色恢复较对照组改善明显,差异有统计学意义(P<0.05);2试验后各组肝功能均有不同程度变化,实验组AST、ALP、GGT较对照组改善明显,差异有统计学意义(P<0.05);3试验结束后,各组血清总胆汁酸、胆红素均不同程度改善,实验组TBA、TBA、TBIL、DBIL较对照组改善明显,差异有统计学意义(P<0.05)。结论:茵栀黄汤对黄疸患儿可改善肝功能,改善消化道功能,促进大便性状、颜色恢复正常,减少排便次数,提高患儿对营养吸收效率,对临床具有指导意义。
Objective: To investigate the effect of Yinzhihuang Decoction on changes of serum total bile acid concentration in neonatal jaundice. Methods: Sixty children with neonatal jaundice admitted to our hospital were randomly divided into two groups, of which 30 cases in the control group were given conventional symptomatic treatment, anti-infection, correct acid-base, ion balance, fluid replacement, And given phenobarbital 5 mg / (kg · d), nicotine 0.25 g, 1 day orally. 1 week for a course of treatment, treatment 2 courses. The experimental group of 30 cases, on the basis of conventional symptomatic treatment in the control group, to Yin Zhihuang Tang (capillaris 10g, Gardenia 5g, Poria 10g, Radix Astragali 10g, Rhubarb 5g, Plantago 5g, Treats 5g , Licorice 10 g), day 1 decoction morning and evening service, 1 week for a course of treatment, treatment 2 courses. After treatment, jaundice and stool status changes, liver function and serum total bile acid and bilirubin levels were compared between groups. Results: After 1 test, the jaundice and stool quality of all groups were improved in a short time. The jaundice in the experimental group subsided, the quality of stools, normal times, and color recovery improved significantly compared with the control group (P <0.05); 2 (P <0.05) .3 After the end of the experiment, the levels of total bile acid, bilirubin in each group were significantly higher than those in the control group (P <0.05) TBA, TBA, TBIL and DBIL in the experimental group were significantly improved compared with the control group, the difference was statistically significant (P <0.05). Conclusion: Yinzhihuang Decoction can improve liver function, improve digestive tract function, promote stool performance, restore normal color, reduce defecation times and improve children’s nutrition absorption efficiency, which is of clinical significance in children with jaundice.