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细胞早衰是指细胞在非端粒信号刺激下发生的增殖能力和生理功能下降，提前进入衰老状态。电离辐射可以引起细胞DNA损伤，随后经过细胞周期永久性停滞或启动SASP来诱导细胞早衰。其信号通路较为复杂，p53、p16、p38MAPK、p62等信号分子参与该过程。本文总结了辐射诱导p62介导的细胞早衰研究进展。“,”Premature cellular senescence refers to the decrease of proliferation and physiological function stimulated by non-telomere signals, promoting early aging. Ionizing radiation can cause DNA damage and induce premature cellular senescence by permanently halting the cell cycle or starting SASP signal factor. The signaling pathways of ionizing radiation-induced premature cellular senescence are complex and may include p53, p16, p38MAPK and p62. This review summarized the research progress of radiation-induced premature cellular senescence mediated by p62/SQSTM1.