论文部分内容阅读
目的探讨急性白血病(AL)患者治疗前后血浆血栓调节蛋白(TM)、蛋白C(PC)抗原、D-二聚体(D-D)含量变化及其临床价值。方法采用酶联免疫吸附检测(ELISA)方法检测22例AL患者治疗前后血浆TM,PC抗原,D-D含量的变化。结果AL患者化疗前血浆TM,D-D升高,PC抗原降低,与正常对照组比较差异有统计学意义(P<0.01)。缓解后,血浆TM,PC抗原均恢复至正常水平,血浆D-D含量比治疗前有明显降低(P<0.01),但仍高于正常水平(P<0.01)。结论AL患者存在不同程度的血管内皮细胞损伤、凝血及纤溶系统的激活,并随病情的好转而逐渐改善。
Objective To investigate the changes of plasma thrombomodulin (TM), protein C (PC) antigen and D-dimer (D-D) in patients with acute leukemia before and after treatment and their clinical value. Methods The changes of plasma TM, PC antigen and D-D in 22 AL patients before and after treatment were detected by enzyme linked immunosorbent assay (ELISA). Results The plasma levels of TM and D-D in patients with AL before chemotherapy were significantly lower than those in normal controls (P <0.01). After remission, the levels of plasma TM and PC antigen recovered to normal level, while the plasma D-D level was significantly lower than that before treatment (P <0.01), but still higher than the normal level (P <0.01). Conclusion AL patients have different degrees of vascular endothelial cell injury, coagulation and fibrinolytic system activation, and with the improvement of the condition gradually improved.