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1 治疗高血压 高血压是肾脏病中的主要临床表现之一,肾排钠功能受损和肾素-血管紧张素系统(RAS)活跃是肾性高血压的重要致病因素。ACEI通过抑制血管紧张素转换酶阻断血管紧张素Ⅱ(ATⅡ)合成,并进而减少醛固酮产生,因此对肾素依赖型及容量依赖型高血压均有效。作者的经验是对轻、中和重度高血压,单独使用ACEI疗效亦佳,不会发生假性耐药性。当其与利尿剂合用,其降
1 Treatment of Hypertension Hypertension is one of the main clinical manifestations of renal disease. Impaired renal function and renin-angiotensin system (RAS) activity are important risk factors of renal hypertension. ACEI blocks renin-angiotensin II (ATII) synthesis by inhibiting angiotensin-converting enzyme and thereby reduces aldosterone production, thus being effective in both renin-dependent and capacity-dependent hypertension. The author’s experience is mild, moderate and severe hypertension, ACEI alone is also effective curative effect, does not occur pseudo-resistance. When used in combination with diuretics, it drops