肿瘤的淋巴道侵袭和转移是癌细胞形成远处转移的主要途径之一,也是导致预后不良的重要因素。近年来,随着一些关键淋巴内皮细胞生长因子的发现,对肿瘤诱导的新生淋巴管形成与淋巴远处转移的研究逐渐增多。现就肿瘤淋巴管生成分子机制及其调控及与淋巴转移、临床预后的关系进展作一综述。 Tumor lymph node invasion and metastasis is the formation of distant metastasis of cancer cells is one of the main ways, but also lead to poor prognosis of the important factors. In recent years, with the discovery of some key lymphatic endothelial cell growth factors, the research on tumor-induced lymphangiogenesis and lymphatic metastasis has gradually increased. Now the molecular mechanism of tumor lymphangiogenesis and its regulation and its relationship with lymph node metastasis, clinical prognosis are reviewed.