研究了用超临界流体萃取法直接从脂肪基质的固体样品（大豆粉）中选择性地萃取有机锡化合物的方法。模拟试样萃取结果表明：用较低压力和较高温度的超临界态ＣＯ２作流动相时，有机锡达到最大萃取率，而脂肪类物质仅被少量萃取，从而消除了脂肪类物质对超临界流体色谱法测定有机锡的干扰。 A method for the selective extraction of organotin compounds from solid samples of fat matrices (soy flour) by supercritical fluid extraction was studied. The results of the simulated sample extraction showed that when the supercritical CO2 with lower pressure and higher temperature was used as the mobile phase, the maximum yield of organotin was achieved, while the fatty substances were only extracted in a small amount, thus eliminating the effects of the fatty substances on the supercritical Determination of Organotin Interference by Fluid Chromatography.