论文部分内容阅读
γ-氨基丁酸(γ-aminobutyric acid,GABA)是一种哺乳动物中枢神经系统重要的抑制性神经递质,GABA通过与不同类型的GABA受体(GABA receptor,GABAR)结合对机体多种功能发挥特异性调节作用。近年来研究发现,GABA与GA-BAR还广泛存在于外周组织,参与细胞间的信息传递,与细胞的分化和成熟密切相关。此外,GABA及其受体还可通过特定的信号转导通路影响某些肿瘤的增殖和侵袭转移等恶性潜能。某些肿瘤伴随GABA及其受体的高表达,阻断GABAR信号则可抑制肿瘤细胞的增殖。GABA与GABAR结合后可通过上调MMP表达、提高胞内钙离子浓度、活化MAPK激酶链等途径促进肿瘤的侵袭和转移。随着研究的深入,GABA及其受体信号通路蛋白分子有可能成为肿瘤诊断与治疗的潜在靶点。
Gamma-aminobutyric acid (GABA) is an important inhibitory neurotransmitter in mammalian central nervous system. GABA binds to various functions of GABA receptor (GABA) Play a specific role in regulation. In recent years, it has been found that GABA and GA-BAR also exist in peripheral tissues extensively and participate in cell-cell information transmission, which is closely related to cell differentiation and maturation. In addition, GABA and its receptors can also affect the malignant potential of some tumors such as proliferation, invasion and metastasis through specific signal transduction pathways. Some tumors accompanied by high expression of GABA and its receptor, blocking GABAR signal can inhibit tumor cell proliferation. Combination of GABA and GABAR can promote tumor invasion and metastasis by up-regulating MMP expression, increasing intracellular calcium concentration and activating MAPK kinase chain. With further research, GABA and its receptor signaling protein molecules may become potential targets for tumor diagnosis and treatment.