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目的探讨不同营养方式早产儿血清胰岛素样生长因子(IGF-I)与生长激素(GH)水平的变化及其与生长发育的关系。方法采用放射免疫法测定观察组(42例)与对照组(48例)早产儿出生时及生后第7d、第14d血清IGF-I、GH水平,同时测量两组早产儿相应日龄体质量、身长、头围,计算Rohrer指数(RI),并进行对比分析。结果 (1)两组早产儿生后第14d血清IGF-I水平与脐血及第7d组内比较差异均有统计学意义(P<0.05)。观察组早产儿生后第7d及第14d血清IGF-I水平与对照组相比,差异有统计学意义(P<0.05)。(2)两组早产儿生后第14d血清GH水平差异有统计学意义(P<0.05)。(3)两组早产儿脐血及生后第7d、第14d血清IGF-I水与体质量、RI及GH分别呈正相关,生后第14d血清GH水平与RI呈正相关(P<0.05)。结论 IGF-I及GH在早产儿营养与生长调控的过程中发挥着一定的作用,与早产儿的营养状况密切相关。
Objective To investigate the changes of serum insulin-like growth factor (IGF-I) and growth hormone (GH) in preterm infants with different nutritional status and its relationship with growth and development. Methods The levels of serum IGF-I and GH at birth and at the 7th day and the 14th day after birth in the observation group (42 cases) and the control group (48 cases) were measured by radioimmunoassay. At the same time, the body weight , Length, head circumference, calculated Rohrer index (RI), and comparative analysis. Results (1) The levels of serum IGF-I on the 14th day after birth in both groups were significantly different from that in cord blood and the 7th day (P <0.05). The level of serum IGF-I on the 7th day and the 14th day after birth in the observation group was significantly higher than that in the control group (P <0.05). (2) There was a significant difference in serum GH levels between the two groups on the 14th day after birth (P <0.05). (3) There was a positive correlation between serum IGF-I and body weight, RI and GH at cord blood of preterm infants and on the 7th day and 14th day after birth. Serum GH level was positively correlated with RI at 14th day after birth (P <0.05). Conclusion IGF-I and GH play a role in the regulation of nutrition and growth in premature infants, and are closely related to the nutritional status of premature infants.