论文部分内容阅读
非酒精性脂肪肝在组织学上包括单纯脂肪肝及非酒精性脂肪肝炎(NASH)。此研究旨在检验与NASH发病有关的假说(1)外周胰岛素抵抗是非酒精性脂肪肝的共同特征;(2)可能存在线粒体的缺陷。 材料与方法:根据临床标准及组织学检查诊断,排除肝硬化、临床糖尿病和病态肥胖。正常对照组的性别、年龄、体重与脂肪肝及NASH组相匹配。 全部测量人体有关指数、口服葡萄糖耐量试验。皮肤活检作纤维母细胞培养。肝活检组织用于电镜观察线粒体异常及免疫组织化学方法检测、评估肝内脂质氧化。
Non-alcoholic fatty liver histologically includes simple fatty liver and non-alcoholic steatohepatitis (NASH). This study was designed to test the hypothesis associated with the pathogenesis of NASH. (1) Peripheral insulin resistance is a common feature of nonalcoholic fatty liver disease; (2) There may be mitochondrial defects. Materials and Methods: According to clinical criteria and histological examination to diagnose, exclude cirrhosis, clinical diabetes and morbid obesity. The normal control group sex, age, body weight and fatty liver and NASH matched. All measured body related index, oral glucose tolerance test. Skin biopsy for fibroblast culture. Liver biopsies were used to observe mitochondrial abnormalities by electron microscopy and immunohistochemistry to assess intrahepatic lipid oxidation.