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本项研究评估蒽环类药物吡柔比星(THP)TURBT术后即刻单次膀胱灌注用于治疗浅表性膀胱癌时,局部组织中药物浓度和暴露时间或疗效的关系。研究入组22例浅表性膀胱癌患者(中低危)经单次膀胱灌注THP(30mg)治疗,间隔一定时间后检测肿瘤组织和血液中THP的浓度。在膀胱癌肿瘤组织中可以检测到不同浓度(范围:2.3~125μg/g组织)THP,而在血液中没有检
This study evaluated the relationship between drug concentration in the local tissue and exposure time or efficacy when single intravesical instillation of the anthracycline, pirarubicin (THP) TURBT, was used to treat superficial bladder cancer. Twenty-two patients with superficial bladder cancer (medium and low risk) were enrolled in this study. THP (30 mg) was given to the patients after a single intravesical instillation of urinary bladder. The concentrations of THP in the tumor tissue and blood were measured at intervals. Different concentrations (range: 2.3-125 μg / g of tissue) of THP were detectable in bladder cancer tissues without detection in the blood