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目的查清本次暴发的流行原因和流行状况。方法采用现场流行病学调查的方法并依据血清学、免疫学以及分子生物学实验结果确认。结果2005年河南省南部淮滨县新里镇大董庄发生一起恙虫病暴发流行,自9月26日~11月10日共发病32人,以成人为主,主要临床表现为发烧、头疼、淋巴结肿大、皮疹。恢复期病人血清外斐氏OXk1∶160实验阳性率100%,最高效价达1∶2560,典型病人的两次血清呈4倍升高;恙虫病荧光抗体阳性率100%,最高效价达1∶2560。血清分型主要是G illiam、Karp、Kato3个血清型;套式PCR检测病人血3份阳性。结论本次为河南首起恙虫病暴发流行。
Objective To find out the epidemic reasons and epidemic situation of this outbreak. Methods The method of field epidemiological survey was used and confirmed according to the serological, immunological and molecular biological experimental results. Results In 2005, an outbreak of scrub typhus was reported in Dali, Xinli Town, Huaibei County, southern Henan Province. From September 26 to November 10, a total of 32 people were mainly affected by adults. The main clinical manifestations were fever, headache, Lymphadenopathy, rash. Conversely, the positive rate of OXK1: 160 experiment in patients with convalescent disease was 100%, the highest titer reached 1: 2560, and the serum of two patients in typical patients increased 4 times. The positive rate of scFv antibody was 100% and the highest titer reached 1 : 2560. Serological typing was mainly G illiam, Karp, Kato3 serotypes; nested PCR detection of 3 patients with positive blood. Conclusion This is the first outbreak of scrub typhus epidemic in Henan.