【摘 要】
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Peptide analogs of salmon calcitonin (sCT) were synthesized by using Fmoc-based chemistry on MBHA resins Salmon calcitonin was modified by 1) cysteines at p0sit
【出 处】
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Chinese Chemical Letters
论文部分内容阅读
Peptide analogs of salmon calcitonin (sCT) were synthesized by using Fmoc-based chemistry on MBHA resins Salmon calcitonin was modified by 1) cysteines at p0sitions 1 and 7 were replaced by valine and alanine respectively to result in open chain analogs. 2) the glycine at position 30 was replaced by alanine, D-alanine and sarcosine respectively, and 3) some residues were deleted besides the above two modifications. A modified two-step deprotection / cleavage procedure, in which a solvent of TFA / TMSBr / thioanisole / EDT / m-cresol combines with HF cleavage,was adopted in SPPS.
Peptide analogs of salmon calcitonin (sCT) were synthesized by using Fmoc-based chemistry on MBHA resins Salmon calcitonin was modified by 1) cysteines at p0sitions 1 and 7 were replaced by valine and alanine respectively to result in open chain analogs. 2) the glycine at position 30 was replaced by alanine, D-alanine and sarcosine respectively, and 3) some modifications were deleted besides the above two modifications. A modified two-step deprotection / cleavage procedure, in which a solvent of TFA / TMSBr / thioanisole / / m-cresol combines with HF cleavage, was adopted in SPPS.
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