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卵巢癌是女性生殖系统3大恶性肿瘤之一,发病率低于宫颈癌和子宫内膜癌,但死亡率却高居妇科肿瘤首位,每年在全世界均是主要的肿瘤死因之一。早期卵巢癌通常没有特异性的临床表现,起病隐匿,临床确诊时肿瘤一般已发生转移[1]。据统计,高达70.00%的卵巢癌患者在晚期才被发现[2]。早期卵巢癌患者5年生存率为80.00%~90.00%,而晚期仅有40.00%,故卵巢癌死亡率在妇科恶性肿瘤中最高[3]。卵巢癌发病机制研究具有重要意
Ovarian cancer is one of the three major malignant tumors of the female reproductive system, the incidence is lower than that of cervical cancer and endometrial cancer, but the mortality rate ranks first in gynecological tumors, each year in the world are one of the major cancer deaths. Early ovarian cancer usually does not have specific clinical manifestations, occult onset, the tumor has generally metastasized clinically [1]. According to statistics, up to 70.00% of ovarian cancer patients were found in late stage [2]. The 5-year survival rate of patients with early ovarian cancer is 80.00% ~ 90.00%, while only 40.00% in late stage, so the ovarian cancer mortality in gynecological malignancies [3]. The pathogenesis of ovarian cancer is of great significance