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目的:研究兴奋性氨基酸NMDA受体拮抗剂地佐环平马来酸盐对甲基苯丙胺辨别行为的作用。方法:采用双杆、固定比率食物强化型辨别实验程序。结果:大鼠对甲基苯丙胺(1.0mg/kg,sc)可以产生辨别行为,并稳定地维持该行为。在用地佐环平马来酸盐(0.1mg/kg,sc)的替代实验中,1只大鼠的行为表明地佐环平马来酸盐无替代作用,其余6只均表明该剂量下地佐环平马来酸盐具有不同程度的替代甲基苯丙胺的辨别效应;但是地佐环平马来酸盐(0.025,0.05mg/kg,sc)均没有替代作用。在拮抗实验中,地佐环平马来酸盐(0.10mg/kg,sc)不同程度地拮抗甲基苯丙胺的辨别效应(P<0.01);而地佐环平马来酸盐(0.025,0.05mg/kg,sc)均没有拮抗甲基苯丙胺的辨别效应的作用。结论:NMDA受体可能与甲基苯丙胺精神依赖性有关。
OBJECTIVE: To study the effect of excitatory amino acid NMDA receptor antagonist, dizocilpine maleate, on the discrimination of methamphetamine. Methods: Double-rod, fixed-ratio food fortification discriminate experimental procedure. Results: Rat methamphetamine (1.0 mg / kg, sc) produced discriminatory behavior and maintained this behavior stably. In an alternative experiment with gefitinib maleate (0.1 mg / kg, sc), the behavior of one rat showed no effect of replacement of the gerolizumab maleate, and the remaining six showed no effect Peripate maleate had varying degrees of discriminatory effect with methamphetamine; however, no effect of substitution was observed with gefitinib maleate (0.025, 0.05 mg / kg, sc). In antagonistic experiments, geratubamazine maleate (0.10 mg / kg, sc) antagonized the discriminatory effect of methamphetamine to varying extents (P <0.01), whereas germabine homomaleate (0.025, 0.05 mg / kg, sc) did not antagonize the discriminatory effect of methamphetamine. Conclusion: NMDA receptors may be related to the psychological dependence of methamphetamine.