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目的探讨高尿酸血症患者的血管内皮功能状况。方法控制影响血管内皮功能的因素后纳入观察组中78例高尿酸血症患者,以及年龄、性别匹配的对照组75名,采用超声检测血管内皮功能进行比较。结果观察组血流介导的血管舒张(FMV)较对照组明显下降(P<0.05),两组在年龄、性别、体质量、血压、血脂、血糖水平差异无统计学意义(P>0.05)。结论高尿酸血症患者存在血管内皮功能障碍,是动脉粥样硬化的危险因素。
Objective To investigate the endothelial function of patients with hyperuricemia. Methods The factors influencing endothelial function were controlled and included in the observation group of 78 patients with hyperuricemia, and age and sex matched control group of 75. Ultrasound was used to detect the vascular endothelial function for comparison. Results The blood flow-mediated vasodilation (FMV) in the observation group was significantly lower than that in the control group (P <0.05). There was no significant difference in age, sex, body weight, blood pressure, . Conclusion Hyperuricemia patients have vascular endothelial dysfunction, which is a risk factor for atherosclerosis.