论文部分内容阅读
为了检测剧烈运动对细胞免疫系统所可能产生的一些免疫调节作用,作者测试了5公里竞赛对11位竞技状态良好的优秀长跑者体内IL-2、TNF-α及淋巴细胞亚群水平的影响。同运动前稳定状态相对比,IL-2水平在运动结束时显著下降(P<0.01),24小时后则显著增高(P<0.05)。TNF-α水平在运动后2小时显著增高(P<0.05),在运动后24小时恢复正常。检测发现所有长跑者在非运动期稳定状态下,其HLA-DR~+细胞数量均高于对照组(P<0.05)。提示存在着持续的淋巴样细胞活化。据观察,NK 细胞(CD_(16)~+)的显著增加与运动相关(P<0.01)。T 辅助细胞/T 抑制细胞(CD_4~+/CD_8~+)的下降与体育活动相关(P<0.01)。在7位长跑者中,比值低于1。
To test some of the immunomodulatory effects that strenuous exercise may have on the cellular immune system, the authors tested the effect of 5 km race on IL-2, TNF-α and lymphocyte subsets in 11 well-run and long-distance runners. Compared with the pre-exercise steady state, IL-2 level decreased significantly at the end of exercise (P <0.01) and significantly increased at 24 hours (P <0.05). TNF-α levels increased significantly 2 hours after exercise (P <0.05), returned to normal 24 hours after exercise. The results showed that the number of HLA-DR ~ + cells of all the long distance runners was higher than that of the control group (P <0.05) during the non-exercise phase. Suggesting that there is sustained activation of lymphoid cells. It was observed that a significant increase in NK cells (CD 16 +) was associated with exercise (P <0.01). The decrease of T helper / T-suppressor cells (CD_4 ~ + / CD_8 ~ +) was associated with physical activity (P <0.01). In seven long distance runners, the ratio is less than one.