一向认为乙胺碘呋酮(amiodarone)是副作用很小的药物。作者在80例用乙胺碘呋酮治疗的病人中,观察到12例(15％)有潜在的致命性反应,分别有4种机制:①4例(5％)复发性室性心动过速病人,用乙胺碘呋酮治疗平均19.5(7～30)日,平均剂量为800(400～1,200)mg/d 后,发生频繁的室性心动过速。均需停药,3例需注射抗心律失常药,1例施行图标引导(map-guided)的心室壁瘤切除术,以控制室性心动过速。 Amiodarone has long been considered as a side-effect drug. Of the 80 patients treated with amiodarone, 12 (15%) had a potentially fatal response, with four mechanisms, respectively: ① Four (5%) patients with recurrent ventricular tachycardia , With amiodarone treatment of an average of 19.5 (7 to 30) days, the average dose of 800 (400 ~ 1,200) mg / d, the occurrence of frequent ventricular tachycardia. All were discontinued, 3 were given antiarrhythmic drugs, and 1 underwent map-guided ventricular aneurysm resection to control ventricular tachycardia.