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目的探析内镜下病灶切除联合局部放化疗治疗食管癌的临床效果。方法本文选择本院2010年6月~2012年12月期间收治的80例中晚期隆起型食管癌患者为研究对象,将其随机分为两组,对照组40例患者采用单独放射治疗,治疗组40例患者在内镜下使用氩气刀切除病灶,植入化疗缓释粒子联合放射治疗,对比分析两种治疗方案的疗效,同时对比分析两组1、2年生存率以及不良反应发生率。结果治疗组治疗总有效率明显高于对照组(P<0.05),1、2年生存率明显高于对照组(P<0.05),不良反应发生率比较差异不具有统计学意义(P>0.05)。结论内镜下氩气刀切除病灶联合局部放化疗治疗中晚期隆起型食管癌治疗效果确切,操作简便,安全性高,值得在临床上广泛推广和应用。
Objective To investigate the clinical effect of endoscopic resection combined with local radiotherapy in the treatment of esophageal cancer. Methods 80 cases of advanced esophageal squamous cell carcinoma treated in our hospital from June 2010 to December 2012 were selected as study subjects and randomly divided into two groups. Forty patients in control group were treated with radiotherapy alone. The treatment group Forty patients underwent endoscopic resection of the lesion with argon knife, and were treated with chemotherapy-controlled release particles combined with radiotherapy. The curative effects of the two treatment regimens were compared and analyzed. The 1-year and 2-year survival rates and the incidence of adverse reactions were compared between the two groups. Results The total effective rate of the treatment group was significantly higher than that of the control group (P <0.05), and the 1-year and 2-year survival rates were significantly higher than those of the control group (P <0.05). The incidence of adverse reactions was not statistically significant (P> 0.05 ). Conclusion Endoscopic argon knife excision combined with local chemoradiotherapy in the treatment of advanced esophageal carcinoma is effective, easy to operate and safe, which is worthy of widespread application in clinic.