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《英国医学杂志》第284卷第6323期第1138页(1982年)报道:妊娠时消化不良常见的现象是胃灼热,这是由于回流进入食管下段所致。根据不同的估计,妊娠妇女中30％～70％有胃灼热。这种现象在妊娠早期就可能发生,但是通常在妊娠第二期和妊娠第三期有这种症状。传统的解释是由于子宫增大,腹内压增加而引起。然而,过去十年对上述假说已表示怀疑,最近匹兹堡的范蒂尔(Van Thiel)研究组又予以驳斥。患严重腹水的男子常作为一种模型,并测定其食管下段括约肌的压力、血浆中胃素的浓度以及基础pH值。排尿前,当腹部压力增加时,括约肌压力也增加。排尿后,当临床上不再出现腹水时,括约肌的压力趋于正常。不论在排尿前或排尿后,没有一个人有胃灼热或回流现象,空腹时胃素基本浓度
The British Medical Journal 284, No. 6323, p 1138 (1982) reports that common symptoms of indigestion during pregnancy are heartburn due to reflux into the lower esophagus. According to different estimates, 30% to 70% of pregnant women have heartburn. This phenomenon may occur in early pregnancy, but usually in the second trimester and the third trimester of pregnancy have this symptom. The traditional explanation is due to increased uterus, increased intra-abdominal pressure caused. However, the above-mentioned hypothesis has been doubted over the past decade, and the recent study by Van Thiel, Pittsburgh, again refutes. Men with severe ascites often served as a model and measured the pressure in the lower esophageal sphincter, the concentration of plasma gastrin, and basal pH. Before micturition, sphincter pressure also increased as abdominal pressure increased. After urination, the pressure on the sphincter tends to be normal when ascites is no longer clinically present. No matter before urination or after urination, no one had heartburn or reflux, fasting when the basic concentration of gastrin