具有免疫抑制功能的Th细胞过去被称为抑制性T淋巴细胞(suppressor T cell),近年来研究发现其能够介导免疫耐受并抑制自身免疫性疾病,故更名为调节性T淋巴细胞(regu-lator T cell,Treg)。越来越多的证据表明,Treg在抑制抗病毒T细胞免疫应答过程中发挥重要的作用。一方面,Treg抑制过强的T细胞免疫应答避免对机体造成过度损伤;另一方面,由于限制了T细胞的抗病毒反应,病毒不能被及时清除而可能引起感染的持续存在,从而导致乙肝病毒感染后疾病慢性化的发生。 Th cells with immunosuppressive functions, formerly known as suppressor T cells, have been found in recent years to be able to mediate immune tolerance and suppress autoimmune diseases and have been renamed regu- lar T lymphocytes -lator T cell, Treg). There is growing evidence that Tregs play an important role in the suppression of antiviral T-cell immune responses. On the one hand, Treg inhibits excessive T cell immune response to avoid excessive damage to the body; on the other hand, due to limited antiviral response of T cells, the virus can not be cleared in time and may lead to the persistence of infection, resulting in hepatitis B virus Chronic disease occurs after infection.