大肠癌是严重威胁人类健康的恶性肿瘤之一。统计资料表明,在世界范围内大肠癌的发病率在恶性肿瘤中已升至第三位。与欧美国家相比,我国大肠癌的发病率也呈逐年上升趋势,且发病年龄明显提前,成为威胁人们健康的主要疾病。多原发大肠癌发生率占大肠癌的4％～13％。近年来,多原发大肠癌发病率有增多趋势,国外文献报告为4％～13.8％,国内报告为2.4％～15.7％。与单发大肠癌相似,多原发大肠癌起病隐匿,早期几乎无任何特征性临床表现,多数确诊时已届晚期。多原发大肠癌细胞增殖背景如何,与单发大肠癌相比是否有更高的恶性行为,目前并不十分清楚。本文旨在进一步分析多原发大肠癌细胞增殖状态,探寻早期确诊多原发大肠癌 Colorectal cancer is one of the most serious cancers that threaten human health. Statistics show that the incidence of colorectal cancer in the world has risen to third place among malignant tumors. Compared with Europe and the United States, the incidence of colorectal cancer in China is also increasing year by year, and the age of onset is significantly advanced, and it has become a major disease that threatens people’s health. The incidence of multiple primary colorectal cancer accounts for 4% to 13% of colorectal cancer. In recent years, the incidence of multiple primary colorectal cancers has increased, with foreign reports of 4% to 13.8% and domestic reports of 2.4% to 15.7%. Similar to single colorectal cancer, multiple primary colorectal cancers are occult onset and there are almost no characteristic clinical manifestations at the early stage. Most cases have been diagnosed late. How is the background of multi-primary colorectal cancer cell proliferation and whether it has a higher malignant behavior than single colorectal cancer? Currently, it is not very clear. This article aims to further analyze multi-primary colorectal cancer cell proliferation and explore the early diagnosis of multiple primary colorectal cancers.