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荧光原位杂交(fluorescence in situ hybridization,FISH)技术是20世纪80年代末在放射性原位杂交技术基础上发展起来的一种非放射性分子细胞遗传技术,其是分子生物学、细胞遗传学及免疫学技术相结合的产物。该技术已广泛应用于分子生物学、医学、细胞遗传学等诸多领域,在产科已用于胚胎植入前遗传学诊断、产前诊断、自然流产和胎儿先天性心脏病的研究。综述FISH技术在产科相关领域的应用。
Fluorescence in situ hybridization (FISH) is a non-radioactive molecular cytogenetic technique developed in the late 1980’s based on radioactive in situ hybridization (FISH). It is a molecular biology, cytogenetics and immunology Learn the combination of technology products. The technology has been widely used in molecular biology, medicine, cytogenetics and many other fields in the obstetrics has been used for preimplantation genetic diagnosis, prenatal diagnosis, spontaneous abortion and fetal congenital heart disease research. Summarizes the application of FISH in obstetrics related fields.