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目的：探讨可溶性细胞间粘附分子（ｓＩＣＡＭ－１）在急性脑血管病（ＡＣＶＤ）发生、发展中的作用。方法：采用酶联免疫吸附方法，测定６２例ＡＣＶＤ患者和２５例对照组血清ｓＩＣＡＭ－１的含量。结果：与对照组相比，ＡＣＶＤ血清ｓＩＣＡＭ－１含量均明显升高（Ｐ＜０．０１），动态观察显示，随着病情的好转，ｓＩＣＡＭ－１含量逐渐下降。ＡＣＶＤ患者头ＣＴ片病灶越大，ｓＩＣＡＭ－１含量升高也越明显。结论：血清ｓＩＣＡＭ－１含量的高低可作为判断ＡＣＶＤ患者病情变化的指标之一。
Objective: To investigate the role of soluble intercellular adhesion molecule (sICAM-1) in the development and progression of acute cerebrovascular disease (ACVD). Methods: Serum sICAM-1 levels were measured in 62 patients with ACVD and 25 controls by enzyme-linked immunosorbent assay. Results: The levels of sICAM-1 in ACVD serum were significantly higher than those in control group (P <0.01). The dynamic observation showed that the sICAM-1 level decreased gradually as the condition improved. The larger the head CT lesion in ACVD patients, the more obvious the increase of sICAM-1 content. Conclusion: The level of sICAM-1 in serum can be used as one of the indicators to judge the change of disease in ACVD patients.