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目的:通过观察选择性雌激素受体调节剂(雷洛昔芬)对放疗去势大鼠的骨代谢生化指标的影响,探讨选择性雌激素受体调节剂对放疗所致卵巢早衰引起骨质丢失的保护作用。方法:选用3月龄雌性wistar大鼠40只,随机分为4组:假放疗组、放疗组、放疗+雷洛昔芬组、放疗+己烯雌酚组,每组10只,16周后,处死大鼠,腹主动脉取血,检测血清雌二醇、卵泡刺激素,骨钙素及碱性磷酸酶。结果:放疗组及放疗+雷洛昔芬组雌二醇水平明显低于假放疗组,差异有显著意义(P<0.05),而卵泡刺激素水平明显高于假放疗组(P<0.05);放疗组骨钙素和碱性磷酸酶明显高于其他组,差异有显著意义,而另3组间差异不显著。结论:大鼠卵巢放疗可致去势;放疗去势后大鼠有骨质丢失,雷洛昔芬对放疗去势后大鼠的骨丢失和己烯雌酚一样有保护作用。
OBJECTIVE: To observe the effects of selective estrogen receptor modulators (raloxifene) on biochemical markers of bone metabolism in ovariectomized rats and to explore the effect of selective estrogen receptor modulators on bone metabolism caused by premature ovarian failure Lost protection. Methods: Forty female Wistar rats of 3 months old were randomly divided into 4 groups: sham radiotherapy group, radiotherapy group, radiotherapy raloxifene group and radiotherapy + diethylstilbestrol group, 10 rats in each group. After 16 weeks, Rats, abdominal aorta blood, serum estradiol, follicle stimulating hormone, osteocalcin and alkaline phosphatase. Results: The estradiol level in radiotherapy and radiotherapy + raloxifene group was significantly lower than that in sham - radiotherapy group (P <0.05), while the follicle stimulating hormone level was significantly higher than that in sham radiotherapy group (P <0.05). Radiotherapy group, osteocalcin and alkaline phosphatase were significantly higher than the other groups, the difference was significant, while the other three groups was no significant difference. CONCLUSION: Ovariectomized rats can castrate ovariectomized rats; bone loss occurs after castration in rats, and raloxifene has the same protective effect on bone loss and diethylstilbestrol after castration in castration rats.