他汀类药物是3-羟基-3-甲基戊二酰辅酶A(3-hydroxy-3-methylglutaryl-coenzyme A,HMG-Co A)还原酶抑制剂,通过抑制胆固醇合成链中的限速酶HMG-Co A还原酶,来减少胆固醇的合成[1]。1999年Mundy等[1]首次发现,他汀类药物有激活成骨细胞、促进骨合成代谢的作用。随后有研究者发现,辛伐他汀能在体内和体外环境 Statins are 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-Co A) reductase inhibitors that inhibit the rate-limiting enzyme HMG in the chain of cholesterol synthesis -Co A reductase, to reduce the cholesterol synthesis [1]. 1999 Mundy et al [1] for the first time found that statins have the effect of activating osteoblasts and promoting bone anabolism. Subsequently, researchers have found that simvastatin can be in the in vivo and in vitro environment