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急性白血病(AL)分类应尽可能客观地反映造血前体细胞或原始细胞增殖方面的多种疾病的生物学和临床特征。免疫学(单克隆抗体),细胞遗传学(染色体异常)和分子遗传学(基因重组)的进展,要求考虑提高诊断精确度和重分类的重复性。 70年代末介绍的FAB分类法,至今仍是研究的基础。近十年此建议的形态学和细胞化学已经改进,新亚型如M7或巨核细胞白血病已被识别。MIC(形态学、免疫学和细胞遗传学)分类建议是重大进展,通过检查染色体易位,某些AL定义更精确,如Ph
The classification of acute leukemia (AL) should reflect as objectively as possible the biological and clinical features of various diseases in hematopoietic precursor or primal cell proliferation. Advances in immunology (monoclonal antibodies), cytogenetics (chromosomal abnormalities), and molecular genetics (genetic recombination) call for improved diagnostic accuracy and reclassification repeatability. The FAB classification introduced in the late 1970s is still the basis of research. The proposed morphological and cytochemical improvements over the last decade have led to the identification of new subtypes such as M7 or megakaryocyte leukemia. The MIC (Morphology, Immunology, and Cytogenetics) classification recommendations are significant advances and some AL definitions are more accurate by examining chromosomal translocations such as Ph