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目的研究药物注射方式对二维实体肿瘤中药物输运的影响,确定较适当的注射方式。方法根据数值生成的肿瘤二维血管网,研究药物的输运。采用肿瘤中各部位药物浓度维持在最小药物浓度MEC水平以上的时间曲面下体积VUS来衡量药物的效果。对不同的施药注射方式进行了探讨。结果MEC较小时各种注射方式效果接近;MEC较大时,比较适合采用短时间集中注射方式。结论对肿瘤进行药物注射策略选取时,应根据肿瘤具体特性,以及药物施加方式对肿瘤细胞产生的不同作用来组合设计相应的优化施药方案。
Objective To study the effects of drug injection on drug delivery in two-dimensional solid tumors and to determine more appropriate injection methods. Methods Based on the numerical generation of a tumor two-dimensional vascular network, study drug transport. The effect of the drug was measured by measuring the volume VUS of the time curve above the minimum drug concentration (MEC) level in each part of the tumor. Different injection methods were discussed. Results MEC less effect of various injection methods close; MEC larger, more suitable for a short time focused injection. Conclusions When drug injection strategy of tumor is selected, the optimal dosage regimen should be designed according to the specific characteristics of tumor and the different effects of drug application on tumor cells.