STUDIES ON RESPONSE CHARACTERISTICS OF DRUG ISE'S (Ⅲ)——ERYTHROMYCIN ELECTRODES AND THEIR SELECT

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Erythromycin sensitive electrodes have been proposed. Their selectivity toward quaternary ammoniums is described in terms of induction effect and steric hindrance effect: logKil=a_1I-a_2Z/R+a_0, where I is induction effect index, a_1,a_2 and a_0 are coefficients which depend on the electro-active material. A general formula has been suggested to relate the electrode selectivity to the carbon atom number (n) of the alkyl of the quaternary ammonium; logK_(ij)=A/2.7~R-B/(0.80+1.26n)+C, where A, B and C are coefficients which depend on the electro-actlve material, logK_(ij) tends to a limited value C when n increases. Their selectivity toward quaternary ammoniums is described in terms of induction effect and steric hindrance effect: logKil = a_1I-a_2Z / R + a_0, where I is induction effect index, a_1, a_2 and a_0 are are which depend depend on the electro-active material. A general formula has been suggested to relate the electrode selectivity to the carbon atom number (n) of the alkyl of the quaternary ammonium; log K_ (ij) = A / 2.7 ~ RB / (0.80 + 1.26n ) + C, where A, B and C are coefficients which depend on the electro-actlve material, logK_ (ij) tends to a limited value C when n increases.
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