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目的 评价从红树林内生真菌Penicillium sp.SCNU-F0003中分离得到的新化合物(+)-(5R,5'R)-3,3'-methylenebistetronic acid (1)和5个已知化合物的潜在活性.方法 通过核磁数据分析和单晶衍射分析确定化合物1的绝对构型,并测定所有化合物的抗氧化活性和α-葡萄糖苷酶抑制活性.结果 化合物1显示中等抗氧化活性,IC50值为81.6 μmol/L,化合物2(IC50=270.3 μmol/L)显示出α-葡萄糖苷酶抑制活性,比阳性药物阿卡波糖(IC50=725.1 μmol/L)活性更好.结论 化合物1和2具有潜在的生物活性.“,”Objective To evaluate potential activity of the new tetronic acid dimer,(+)-(5R,5'R)-3,3'-methylenebistetronic acid (1),isolated from an endophytic fungus Penicillium sp.SCNU-F0003,along with five known compounds.Methods The structure including absolute configuration of 1 was elucidated by extensive spectroscopic data and X-ray diffraction analysis.The antioxidant activity and a-glucosidase inhibitory activity were assayed for all the isolated compounds.Results Compound 1 exhibited moderate antioxidant activity with an IC50 value of 8 1.6 μmol/L and compound 2 showed more potential a-glucosidase inhibitory activity (IC50 =270.3 μmol/L) than the positive control acarbose (IC50 =725.1 μmol/L).Conclusion Compounds 1 and 2 had potential biological activities.