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目的 探讨红霉素对小儿支气管哮喘并感染时的疗效及其机制。方法 81 例患儿随机分为两组,观察组38例,对照组43例。两组病例均常规吸氧、激素、氨茶碱及对症支持治疗。观察组采用红霉素、对照组采用头孢唑啉钠抗感染治疗。结果 观察组总有效率97.37%,对照组79 .07%(χ2=6.52,P<0.05);但两组病例中有效病例的体温下降天数、哮鸣音消失天数及住院天数比较差异均无显著意义(P>0.05)。结论 小儿支气管哮喘并感染时选用红霉素治疗,总有效率高于对照组(头孢唑啉钠),其疗效机制可能与红霉素对感染病原(包括衣原体、支原体等)的敏感性较高有关。但未能显示红霉素有直接的解痉、平喘作用。
Objective To investigate the efficacy and mechanism of erythromycin in children with bronchial asthma and infection. Methods Eighty-one children were randomly divided into two groups: observation group (38 cases) and control group (43 cases). Two groups of patients were routine oxygen, hormones, aminophylline and symptomatic and supportive treatment. Erythromycin was used in observation group and cefazolin sodium was used as anti-infection in control group. Results The total effective rate was 97.37% in the observation group and 79.07% in the control group (χ2 = 6.52, P <0.05). However, there was no significant difference in days of hypothermia, disappearance of wheeze and days of hospitalization among the two groups Significance (P> 0.05). Conclusions Children with bronchial asthma who are infected with erythromycin should have a higher total effective rate than those of the control group (cefazolin sodium). The therapeutic mechanism may be that erythromycin is more susceptible to infectious pathogens (including chlamydia, mycoplasma, etc.) related. But failed to show that erythromycin has a direct antispasmodic, antiasthmatic effect.