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MicroRNA(miRNA)是一类广泛分布于动植物的非编码小RNA,通过与mRNA互补结合转录后抑制靶基因的表达。研究表明一些miRNAs通过调控肿瘤相关基因表达参与肿瘤的发生、发展,具有癌基因或抑癌基因的相关功能。miRNA在喉癌中存在差异表达,参与喉癌的分子发病机制。
MicroRNAs (miRNAs) are a class of non-coding small RNAs widely distributed in animals and plants. They inhibit the expression of target genes by binding to mRNA after transcriptional complementation. Studies have shown that some miRNAs are involved in the development and progression of tumors by regulating the expression of tumor-related genes and have the related functions of oncogenes or tumor suppressor genes. MiRNAs are differentially expressed in laryngeal cancer and are involved in the molecular pathogenesis of laryngeal cancer.