目的研究不同体重指数(BMI)范围的高血压患者其胰岛β细胞早期分泌相的改变。方法选取2003年在我院门诊和住院的高血压患者70例,将其按体重指数分为3组:A组BMI<25,B组BMI25～30,C组BMI>30;通过注射左旋精氨酸(L-ARG),观察胰岛β细胞早期分泌相的改变。结果B组与A组相比,空腹胰岛素(INS)和C-肽(C-P)均明显升高(P<0.01),C组与B组相比,亦有明显差异(P<0.05);L-ARG刺激试验后,B、C两组峰时延迟;B组与A组相比,各时间点的INS和C-P比空腹增加值之和()明显升高(P<0.05)。结论高血压患者的体重指数越大,高胰岛素血症就越严重,胰岛β细胞早期分泌功能就越差,发生糖尿病的危险就越大。 Objective To study the changes of the early secretory phase of pancreatic β cells in hypertensive patients with different body mass index (BMI). Methods Seventy patients with hypertension and outpatients in our hospital in 2003 were divided into three groups according to body mass index: BMI <25 in group A, BMI 25-30 in group B, BMI> 30 in group C; Acid (L-ARG) to observe the changes of the early secretory phase of islet β cells. Results Compared with group A, fasting insulin (INS) and C-peptide (CP) were significantly increased in group B (P <0.01). There was also a significant difference between group C and group B (P <0.05); L -ARG stimulation test, the peak time of B and C groups was delayed. Compared with group A, the sum of INS and CP at all time points was significantly higher than that of group A (P <0.05). Conclusion The higher the body mass index of hypertensive patients, the more severe hyperinsulinemia and the worse the early secretory function of pancreatic β-cells, the greater the risk of diabetes.