在过去40年中,感染白喉的成年人数量有所增加。尽管大多数人已接种过白喉菌苗,但仅有不到50％的人具有保护水平的血清抗毒素。本研究通过检测成年人血清白喉抗毒素水平,评价了影响抗白喉免疫力的因素。作者采集了287份有明确白喉免疫史的成年人(女性154名,男性133名,平均年龄26.4岁)血样,保存于-20℃,用改良组织培养毒素中和分析法检测白喉抗毒素水平。 The number of adults infected with diphtheria has increased over the past 40 years. Although most people have been vaccinated against diphtheria, less than 50% have a protective level of serum antitoxin. In this study, the level of serum anti-diphtheria antitoxin in adults was evaluated, and the factors affecting anti-diphtheria immunity were evaluated. The authors collected blood samples from 287 adults (154 females, 133 males, mean age 26.4 years) with a clear history of diphtheria and stored at -20 ° C. The levels of diphtheria anti-toxin were determined using a modified tissue culture toxin neutralization assay.