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本文应用P53蛋白单克隆抗体,检测42例甲状腺瘤及36例甲状腺癌。结果发现,相当数量甲状腺癌和甲状腺腺瘤有P53蛋白表达。阳性产物定位于癌细胞核。揭示突变型P53蛋白与甲状腺肿瘤发生、发展及预后有关。
This article uses P53 monoclonal antibody to detect 42 cases of thyroid tumors and 36 cases of thyroid cancer. The results showed that a significant number of thyroid cancer and thyroid adenomas have P53 protein expression. Positive products are located in the cancer cell nuclei. The discovery of mutant P53 protein is related to the occurrence, development and prognosis of thyroid tumors.