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核仁组成区(Nucleolar OrganizerRegions,NORs)是位于细胞核仁内的DNA环,其具有转录rRNA及参与合成核仁的功能。由于NORs蛋白具有嗜银性,用胶银染色技术显示染色体核仁组成区(AgNORs),可作为判断细胞增生与分化程度的一项形态定量指标。本文作者应用AgNORs染色技术,对食管癌手术标本各部位组织细胞核内AgNORs的形态及数目进行观察和对比分析,旨在为食管癌的细胞学诊断提供客观的病理诊断指标。
Nucleolar Organizer Regions (NORs) are DNA loops located in the nucleus of a cell, which have the function of transcription of rRNA and participation in the synthesis of nucleoli. Because NORs are auxiliarily silver, the nucleolus karyotypes (AgNORs) are shown by gel silver staining technique, which can be used as a morphological quantitative index to judge the extent of cell proliferation and differentiation. The authors used AgNORs staining technique to observe and contrast the morphology and number of AgNORs in the nucleus of various parts of surgical specimens of esophageal cancer in order to provide an objective pathological diagnosis index for the cytological diagnosis of esophageal cancer.