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肿瘤细胞侵袭与转移是个连续动态过程,包括肿瘤细胞粘附侵袭基底膜,穿入血管或淋巴管,在循环系统中存活,形成瘤栓并运送到远隔靶器官,滞留于靶器官的微小血管中,穿出血管并逐渐形成转移癌灶。其中整合素的粘附介导始终起着重要作用,成为近年来肿瘤侵袭转移机制中的研究热点。一、整合素的结构、表达及其生物学作用整合素是一族细胞表面由一个α亚单位与一个
Invasion and metastasis of tumor cells is a continuous dynamic process, including tumor cell adhesion and invasion of the basement membrane, penetration of blood vessels or lymphatic vessels, survival in the circulatory system, formation of tumor thrombi and transport to distant target organs, and retention of small blood vessels in target organs. In the middle, blood vessels are pierced and gradually form metastatic foci. The integrin-mediated adhesion has always played an important role and has become a research hotspot in the invasion and metastasis mechanism of tumors in recent years. First, the structure, expression and biological role of integrins Integrins are a family of cell surfaces composed of an alpha subunit and a