单纯疱疹病毒2型(HSV-2)是目前最常见的性传播感染疾病之一,其感染生殖器黏膜并可增加其他性传播感染的风险,妊娠感染生殖器疱疹可致胎儿流产、胎儿永久性神经损伤等不良后果,严重影响出生人口质量。Toll样受体(Toll-like receptors,TLRs)是一类可识别多种病原微生物的高度保守的分子,属于机体固有免疫中的模式识别受体(pattern recognition receptors,PRR)。近年来,越来越多的研 Herpes Simplex Virus 2 (HSV-2) is by far one of the most common sexually transmitted infections that infect genital mucosa and increases the risk of other sexually transmitted infections. Pregnancy-infected genital herpes can cause fetal miscarriage, fetal permanent nerve injury And other adverse consequences, seriously affecting the quality of the birth population. Toll-like receptors (TLRs) are a class of highly conserved molecules that recognize a variety of pathogenic microorganisms and belong to pattern recognition receptors (PRRs) in the innate immune system. In recent years, more and more research