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氟哌酸是一种具有抑制局部异构酶Ⅱ作用的强效抗菌剂。因意外发现该药对恶性疟原虫和绿脓杆菌都有杀灭作用,故作者用该药治疗无并发症的恶性疟。作者治疗了9例住院的恶性疟患者,男性7例,女性2例;平均年龄为28.1岁。末梢血涂片均检测到恶性疟原虫的无性体。凡病情严重、有并发症(如脑型疟疾)、重症疟原虫血症者(感染疟原虫的红细胞数>5％),或有近期接受抗疟治疗者,均不列入本项研究。对病人是否感染了抗氯喹的疟原虫未做研究。所有病人均用氟哌酸口服治疗,每12小时0.4g,连服3天。
Norfloxacin is a potent antimicrobial agent that inhibits the action of topoisomerase II. The accidental discovery of the drug has a killing effect on Plasmodium falciparum and Pseudomonas aeruginosa, so the author used the drug to treat falciparum falciparum without complications. The authors treated 9 hospitalized patients with falciparum malaria, 7 males and 2 females; mean age was 28.1 years. The peripheral blood smear detected P. falciparum asexual. Those with severe illness, complications (such as cerebral malaria), severe Plasmodium (> 5% of erythrocytes infected with Plasmodium), or recent anti-malarial treatment were excluded from the study. No studies have been conducted on whether the patient is infected with chloroquine-resistant Plasmodium. All patients were treated with norfloxacin orally, 0.4g every 12 hours, even for 3 days.