低取代羟丙基纤维素(L-HPC)是深受国内外制药行业欢迎的新型辅料之一。作为片剂辅料,它既能提高片剂硬度,改善其外观质量,又能加速片剂的崩解,促进药物溶出,从而提高片剂的生物利用度。我厂在葡萄糖酸锌片的生产中应用了L-HPC,收到满意的效果。按传统处方工艺生产的葡萄糖酸锌片,片子经常出现麻面、花斑、飞边、硬度差、易裂片等现象,从而直接影响产品的质量及经济效益。试用L-HPC后,产品质量稳定,符合部颁药品标准。新旧处方工艺产品的 Low-substituted hydroxypropyl cellulose (L-HPC) is well received by the pharmaceutical industry at home and abroad one of the new accessories. As a tablet excipient, it not only improves the hardness of the tablet, improves the appearance quality, but also accelerates the disintegration of the tablet and promotes the dissolution of the drug so as to improve the bioavailability of the tablet. I plant in the production of zinc gluconate used in the L-HPC, received satisfactory results. According to the traditional prescription production of zinc gluconate tablets, the film often appear Ma face, piebald, flash, hardness, easy to break the film and other phenomena, which directly affect the quality of products and economic benefits. Trial L-HPC, the product quality is stable, in line with the ministerial drug standards. New and old prescription craft products