儿童成骨不全症 (脆骨病 )临床上少见。目前认为是由遗传性中胚层发育障碍造成结缔组织异常所致 ,有明显遗传因素 ,女性较多[1 ] 。现将我们见到的 1例报告如下。患儿 ,男 ,12岁。 1993年 8月送入我院收养。患儿长期行走困难 ,易跌跤 ,入院后因轻微碰撞致双下肢骨折 4次。体查 Children’s osteogenesis imperfecta (brittle bone disease) clinically rare. Currently considered to be caused by genetic disorders of mesoderm caused by abnormal connective tissue, there are obvious genetic factors, more women [1]. Now we see a report as follows. Children, male, 12 years old. August 1993 into our hospital adoption. Children with long-term difficulties in walking, easy to fall, due to minor collisions caused by lower limb fractures after admission 4 times. Physical examination