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选择经集体诊断的矽肺０＋４３例，Ⅰ期矽肺４５例，Ⅱ期矽肺３９例，Ⅲ期矽肺３例，非矽肺患者接尘工人４７例，进行超氧化物歧化酶（ＳＯＤ）及过氧化脂质（ＬＰＯ）测定。结果随着矽肺病变化和发展，机体血清的总ＳＯＤ活力呈显著下降趋势，而各期矽肺患者血清ＬＰＯ含量均显著高于对照组（Ｐ＜０．００１），随矽肺病变增加，ＬＰＯ水平呈显著上升趋势，表明矽肺发生与机体自由基代谢平衡有关，表现为自由基反应的增强和抗氧化能力的减弱。
There were 0 + 43 cases of silicosis, 45 cases of stage I silicosis, 39 cases of stage II silicosis, 3 cases of stage III silicosis and 47 cases of non-silicosis patients dust-intensive workers. Superoxide dismutase (SOD) and lipid peroxidation (LPO) determination. Results With the change and development of silicosis, the total serum SOD activity decreased significantly, while the serum LPO levels in all stages of silicosis patients were significantly higher than those in the control group (P <0.001). With the increase of silicosis, LPO level Significant upward trend, indicating that the occurrence of silicosis and the body’s free radical metabolism is related to the performance of free radical reaction and antioxidant capacity decreased.